Inositol formulas have become a mainstream category in women’s health, and most of them combine two closely related molecules: myo-inositol and D-chiro-inositol (DCI). The two isomers sound interchangeable, but they play different roles in cell signalling and hormone-related nutrition, and the ratio between them is the key formulation decision. This guide explains the chemistry, the evidence behind the 40:1 ratio and how to specify each powder. Core Nutrix supplies myo-inositol at 95-99% purity by HPLC (CAS 87-89-8) and D-chiro-inositol at 98% purity (CAS 643-12-9).
Two Isomers, Different Jobs
- Myo-inositol is the most abundant inositol in the body and is the form cells use for signal transduction, and the form studied in relation to follicle maturation and egg quality.
- D-chiro-inositol is produced from myo-inositol by an epimerase enzyme and mediates specific metabolic actions, including glycogen synthesis.
- The inositol connection: research suggests some women convert myo to DCI less efficiently in certain tissues, which is why supplementation of both isomers – in a specific ratio – became the clinical approach.
The 40:1 Ratio Used in Clinical Studies
The physiological ratio of myo-inositol to D-chiro-inositol in plasma is roughly 40:1, and the most-cited inositol studies mirrored it: 4,000 mg of myo-inositol plus 100 mg of D-chiro-inositol per day, or a 2,000 mg plus 50 mg variant. This combination is associated with changes in ovarian and related markers in the study populations. Notably, several trials that used high doses of D-chiro-inositol alone reported poorer outcomes, which is why finished products almost always keep DCI at the small, physiological-ratio amount rather than dosing the isomers equally.
Dose and Format Design
- Myo-inositol: 2,000-4,000 mg per day, which means sachets, sticks or multiple capsules. Because the dose is large, freely water-soluble myo-inositol is ideal for drink powders and shots.
- DCI: 50-100 mg per day, comfortably delivered in one capsule or a small portion of a sachet blend.
- Blends: most products premix the two isomers at 40:1 (for example 2,000 mg myo + 50 mg DCI per serving) so the consumer gets the studied ratio from a single scoop or packet.
Specification and Solubility
- Myo-inositol: 95-99% purity by HPLC, CAS 87-89-8, white crystalline powder or granular direct-compression grade, freely soluble in water and nearly tasteless – which keeps drink formulations clean.
- D-chiro-inositol: 98% purity, CAS 643-12-9, white fine powder suited to capsules, tablets and precision blending in sachets.
- Granulation: our DC granular myo-inositol improves flow and compressibility for tablet lines, a practical advantage when dosing grams per serving.
Quality Checks That Matter
- Identity: myo-inositol and D-chiro-inositol are stereoisomers with different CAS numbers; the COA must identify the correct isomer, since a substitution silently changes the formula.
- Assay: HPLC purity with the method stated, plus heavy metals, residual solvents and microbiology.
- Mesh and flow: particle-size data for tablet and capsule filling, and blend uniformity documentation for premixed 40:1 blends.
How Each Isomer Is Produced and Verified
Myo-inositol is produced at scale from plant phytate sources such as rice bran or corn, hydrolyzed and crystallized into a white powder; the direct-compression granular grade is then prepared for high-speed tablet lines. D-chiro-inositol is rarer in nature – it is obtained from carob pod pinitol or by enzyme conversion of myo-inositol – which is why DCI costs far more per gram.
- Myo-inositol: 95-99% purity by HPLC, CAS 87-89-8, freely soluble and nearly tasteless – ideal for grams-per-serving drink formats.
- D-chiro-inositol: 98% purity, CAS 643-12-9, white fine powder for capsules, tablets and precision sachet blends.
- Identity is everything: the two isomers look alike but have different CAS numbers and jobs; the COA must identify the correct isomer and state the HPLC method.
- Blend production: we premix the two isomers to your target ratio – typically 40:1 – with blend uniformity documented for each batch.
Because a silent isomer substitution would quietly change the formula’s physiology, treat identity testing as non-negotiable: check the CAS number on every COA and consider an independent assay for your first bulk delivery.
Frequently Asked Questions (FAQ)
Why not use D-chiro-inositol alone?
Clinical studies that used high-dose DCI alone reported poorer outcomes. The physiological ratio is roughly 40:1 myo to DCI, and finished products keep DCI at that small, supporting amount.
Is D-chiro-inositol a stronger version of myo-inositol?
No. They are different molecules with different roles – myo-inositol is the more abundant isomer and the main focus of the research literature, while DCI mediates specific metabolic actions. The 40:1 ratio, not a single isomer, is the evidence-based approach.
Can myo-inositol be used in drinks?
Yes. Myo-inositol is freely soluble in water and nearly tasteless, which makes it ideal for sachets, sticks, effervescents and ready-to-mix powders.
What are DC granules?
Direct-compression granules are a pre-processed form of myo-inositol with improved flow and compressibility, designed for high-speed tablet production.
What documentation ships with each batch?
Every batch ships with a COA and MSDS showing HPLC purity, the correct CAS number, and the contaminant panel. Third-party testing is available on request.
What is the MOQ for inositols?
Samples start at 0.5-1 kg depending on the item, and bulk ships in 25 kg drums (premium items from 5-10 kg). Premixed myo:DCI blends can be produced to your target ratio on request.
Which isomer is more expensive, and why?
D-chiro-inositol is more expensive because it occurs far less in nature and requires additional conversion steps. Because formulas use it at 1/40th of the myo dose, its impact on cost per serving stays modest, even though the per-kilo price is several times higher than myo-inositol.
Can you produce the 40:1 premix directly?
Yes. We supply myo-inositol and D-chiro-inositol individually or premixed to your ratio – most commonly 2,000 mg myo with 50 mg DCI per serving – with blend uniformity documented per batch.
How is purity verified?
By HPLC with the method and CAS number stated on the COA, plus heavy metals, residual solvents and microbiology. Third-party testing through SGS or Eurofins is available on request.
What particle sizes are available for capsules and tablets?
DCI is supplied as a fine powder for capsules, and myo-inositol is available as powder or DC granules for direct-compression tablet production. Mesh data is on the specification sheet.
View D-Chiro-Inositol Request Free Samples Contact Us
What you can expect from Core Nutrix
- Every batch released against the specification you approve, with a full COA (assay by HPLC/UV, heavy metals, microbiology, residual solvents, pesticide residue screened to EU MRLs).
- Free samples with COA and MSDS - freight collect, credited against your first bulk order.
- Third-party test reports, allergen and GMO statements, shelf-life and stability data supplied on request.
- Documentation support for your market entry: EU Regulation (EC) No 1924/2006 on nutrition and health claims, US 21 CFR 101.93 structure/function support, California Proposition 65 statements.
- One working day to a quotation, OEM/ODM projects from 100-500 kg, private label, custom specifications and packaging.
This is technical, business-to-business information for manufacturers and brand owners - not a consumer label and not medical advice. Where a claim is made about a finished consumer product, it must comply with the rules of the destination market; we supply the supporting technical documentation so your team can review it. Ask us for anything your market requires - we are glad to help.
Отличная статья. Мы уже заказывали у вас мио-инозитол и остались довольны качеством. Подтверждаю, что растворимость в воде отличная, наши клиенты не жалуются на вкус. Рекомендую для производства напитков.
Yes, we offer OEM/ODM with custom particle size and packaging. MOQ for private label is typically 25 kg per drum. Lead time is 7-15 days depending on customization. Contact us for a detailed quote. – Core Nutrix Team
We are a brand in India looking for private label capsules. Do you offer OEM with custom blister packaging? What is the minimum order for a full private label run?
Świetny materiał. Zastanawiam się nad produkcją saszetek z proszkiem; czy moglibyście dostarczyć mio-inozytol o większej granulacji, żeby uniknąć pylenia przy pakowaniu?
هل يمكنكم توفير عينة مجانية من مايو-إينوزيتول مع شحن إلى الرياض؟ ما هي المدة المتوقعة للوصول عبر البريد السريع؟
نعم، نوفر عينات مجانية، وتتحمل أنت تكلفة الشحن. نرسل عبر DHL خلال 1-3 أيام، والوصول إلى الرياض عادة خلال 4-6 أيام. جميع الوثائق مرفقة مع الشحنة. – Core Nutrix Team
Für 25 kg beginnen wir bei einem wettbewerbsfähigen Preis; Staffelrabatte gelten ab 50 kg. Seefracht nach Schweden ist möglich (FOB oder CIF). COA und MSDS sind jeder Sendung beigefügt. – Core Nutrix Team
Article très clair. La distinction entre myo et DCI est souvent mal comprise dans l’industrie. Nous utilisons déjà le ratio 40:1 dans nos gélules et la traçabilité HPLC que vous proposez est un vrai plus pour nos dossiers de conformité.
Viermeldungen: Wir kaufen normalerweise 100 kg pro Charge. Können Sie mir einen Staffelpreis für DCI bei 25 kg, 50 kg und 100 kg nennen? Versand nach Schweden per Seefracht ist für uns interessant.
Muito obrigado pelo guia. Como importador no Egito, gostaria de saber mais sobre os certificados Halal e Kosher que vocês mencionam. Isso é um diferencial importante para o nosso mercado.
A mio-inositol é estável em pH ácido e solúvel em água. Recomendamos testes de estabilidade acelerada com seu blend. Podemos fornecer amostras para validação e especificações de partícula personalizadas. – Core Nutrix Team
A mio-inositol é estável em bebidas com pH ácido? Estamos desenvolvendo um stick efervescente com vitamina C e queremos garantir que a solubilidade e a vida útil de 24 meses sejam mantidas.
Excelente artigo. Já tínhamos testado fórmulas com 100% de mio-inositol e os resultados eram bons, mas ao ajustar para a proporção 40:1 as pacientes relataram menos efeitos colaterais. A clareza sobre a diferença entre os dois isômeros é essencial para quem formula para SOP.
Amostras padrão são 1 kg, mas podemos avaliar 5 kg como pedido piloto. Enviamos por DHL em até 3 dias após confirmação. Para volumes maiores, o prazo de 7 a 15 dias. – Core Nutrix Team
Preciso de 5 kg de D-chiro-inositol para teste de formulação. Vocês aceitam pedido de amostra nesse volume ou o mínimo é realmente 1 kg? Qual o prazo para envio ao Brasil?
La vida útil es de 24 meses en envase sellado. Almacenar en lugar fresco y seco, protegido de la luz. En climas cálidos, mantener bajo 25°C es recomendable. – Core Nutrix Team
¿Cuál es la vida útil del producto y cómo debo almacenarlo en un clima cálido como el de Chile?
Yes, we can provide stability data on request. Each batch is tested with HPLC/UV and full traceability. Please contact us with your specific requirements. – Core Nutrix Team
Precies wat ik zocht. De uitleg over de verhouding 40:1 is helder en onderbouwd. We gebruiken myo-inositol nu in onze drinkformules – het is bijna smaakloos, perfect voor de Nederlandse markt.
Do you provide stability data for Myo-Inositol? We need it for our regulatory submission in India.
Articolo tecnico ma molto leggibile. Il confronto tra i due isomeri è chiaro e supportato da dati. Noi usiamo il rapporto 40:1 nelle nostre capsule e i risultati sono ottimi.
نعم، كل شحنة تأتي مع شهادة التحليل (COA) وMSDS. لا يوجد وكيل حالي في المغرب، لكننا نشحن عبر DHL/FedEx مباشرة مع تتبع كامل. – Core Nutrix Team
هل يمكنكم توفير شهادة التحليل مع كل شحنة؟ وهل لديكم وكيل في المغرب؟
Bra att ni tar upp skillnaden mellan isomererna. Många kunder tror att DCI är en starkare variant. Artikeln ger oss verktyg att förklara varför 40:1 är rätt väg. Tack!
한국으로 배송 시 관세 포함 가격으로 견적 가능한가요? DDP 조건으로 25kg 주문하고 싶습니다.
네, DDP 조건으로 한국까지 관세 포함 견적 가능합니다. 25kg 주문 시 항공운송으로 7-10일 소요됩니다. 별도 요청 시 COA와 MSDS 제공. – Core Nutrix Team
As a formulator, I appreciate the clarity on solubility. We’ve been using myo-inositol in effervescent tablets – the taste profile is perfect. The 40:1 ratio article confirms our approach.
Sim, oferecemos private label com embalagem personalizada, incluindo sachês de 5g. O prazo é de 15-20 dias após aprovação da arte. Entre em contato para detalhes. – Core Nutrix Team
Endlich ein Artikel, der die 40:1 Ratio verständlich erklärt. Wir hatten mehrere Lieferanten, die nur DCI verkaufen wollten. Gut zu wissen, dass die Evidenz anders aussieht. Sehr hilfreich für unsere Produktentwicklung.
Vocês têm opção de embalagem personalizada para private label? Precisamos de sachês com 5g cada.
What is your payment terms for new customers? Do you accept LC for bulk orders?
We accept T/T, LC, and other standard terms for bulk orders. For new customers, 30% deposit and 70% before shipment is typical. Contact us for specifics. – Core Nutrix Team
Sì, i campioni sono gratuiti (spedizione a carico del cliente). Spediamo in 1-3 giorni con DHL Express; consegna in Italia in 3-5 giorni lavorativi. – Core Nutrix Team
The explanation about why DCI alone doesn’t work is spot on. We had a bad experience with a supplier pushing high-DCI formulas. Switched to 40:1 and our customers noticed the difference.
È possibile avere un campione gratuito di DCI per testare la stabilità nella nostra formulazione? Quali sono i tempi di spedizione in Italia?
Artikel yang sangat membantu. Kami di Indonesia sering kesulitan menjelaskan perbedaan kedua isomer ini ke pelanggan. Sekarang punya referensi yang jelas tentang rasio 40:1. Terima kasih.
El precio varía según volumen y especificación. Para 100 kg ofrecemos precio por escala. Por favor contáctenos para una cotización detallada según sus requisitos. – Core Nutrix Team
¿Cuál es el precio por kilo para Myo-Inositol en cantidades de 100 kg? ¿Ofrecen descuentos por volumen?
Bardzo przydatny artykuł. Jako producent suplementów doceniam konkretne dane o rozpuszczalności. Zawsze mieliśmy problem z formułowaniem napojów – teraz wiemy, że myo-inositol się do tego nadaje.
Yes, we offer third-party testing for heavy metals and microbials on request. Each batch is tested by HPLC/UV with full traceability. Certificates and reports are provided with the shipment. – Core Nutrix Team
Do you have third-party testing available for heavy metals and microbials on the Myo-Inositol batch? We need this for EU compliance.
En tant que formulateur, je confirme que le myo-inositol est très facile à utiliser en boisson. Le goût neutre change tout. Article très professionnel avec les bonnes références cliniques.
Gửi mẫu đến Việt Nam bằng đường hàng không mất bao lâu? Chúng tôi cần kiểm tra chất lượng trước khi đặt 100kg.
Gửi mẫu bằng DHL mất 5-7 ngày đến Việt Nam. Mẫu miễn phí, khách trả cước. Đơn 100kg giao trong 7-15 ngày. Chúng tôi gửi COA và MSDS kèm lô hàng. – Core Nutrix Team
Muy buen artículo. Estamos formulando un producto para el mercado argentino y necesitábamos confirmar el ratio. La nota sobre que el DCI no es una versión más fuerte del MI es clave para educar a los clientes.
Tak, oferujemy OEM/private label z własną specyfikacją, pakowaniem i etykietą. Czas realizacji 15-20 dni dla standardowych zamówień. Prosimy o kontakt w celu omówienia szczegółów. – Core Nutrix Team
Czy oferujecie prywatną markę (private label) dla saszetek z proszkiem? Jaki jest minimalny czas realizacji?
We import to Egypt and always check for Halal certification. Good to know you have it available. The 40:1 ratio explanation helps us when talking to our distributors about why the formula isn’t just myo-inositol.
Qual o prazo de validade do D-Chiro-Inositol? E como devemos armazenar em nosso depósito no Brasil?
O prazo de validade é de 24 meses. Armazenar em local fresco e seco, dentro da embalagem selada. Enviamos com COA e MSDS. – Core Nutrix Team
The 40:1 ratio is something we’ve been questioned about by Japanese regulators. This article gives us solid grounds for our formulation documentation. The solubility data for drinks is also practical for our sachet line.
Ja, we verzenden met DHL Express naar Nederland. Monsters worden binnen 1-3 dagen verzonden; levertijd is meestal 3-5 werkdagen. – Core Nutrix Team
Verzenden jullie ook naar Nederland met DHL Express? Wat is de levertijd voor een monster van Myo-Inositol?
Ótimo artigo! Uso a proporção 40:1 há dois anos nos meus produtos. O ponto sobre o DCI isolado ser pior para os ovários é algo que muitos fabricantes ignoram. Bom ver isso documentado.
Können Sie die DCI-Partikelgröße für eine Kapselformulierung anpassen? Wir brauchen eine gute Fließfähigkeit in der Produktion.
Ja, wir bieten OEM/ODM mit angepasster Partikelgröße an. Für Kapseln können wir eine fließfähige Spezifikation herstellen. Mindestbestellmenge 25 kg. – Core Nutrix Team
Articolo molto chiaro. Noi produciamo stick per il mercato italiano e la solubilità del myo-inositolo è fondamentale. Il rapporto 40:1 è un dato che i nostri clienti chiedono spesso. Grazie per la spiegazione tecnica.
هل لديكم شهادة حلال للمنتج؟ وهل يمكن الشحن إلى السعودية خلال أسبوعين؟
نعم، نوفر شهادة حلال عند الطلب. الشحن الجوي إلى السعودية يستغرق 5-7 أيام بعد تجهيز الطلب. نرسل مع كل شحنة COA وMSDS. – Core Nutrix Team
Good breakdown. We’ve been using 2000mg myo + 50mg DCI in our capsules based on clinical protocols. Your spec guidance aligns with what we’ve seen in practice. Bookmarking this for our next formulation review.
Работаем по EXW, FOB, CIF и DDP. Для 25 кг возможна оплата по банковскому переводу. Срок поставки DDP до Москвы — 15-20 дней. – Core Nutrix Team
Какие условия оплаты для заказа 25 кг? Можно ли работать по DDP до Москвы?
As a brand owner in Lagos, I appreciate suppliers who understand formulation constraints. The 40:1 ratio data helps me explain to my customers why we don’t just load up on DCI. Thanks for the clarity.
Tak, próbki są bezpłatne – pokrywasz tylko koszt przesyłki. Wysyłamy w 1-3 dni. Mamy specyfikację o wysokiej rozpuszczalności dla napojów instant. – Core Nutrix Team
Czy mogę otrzymać próbkę Myo-Inositol do testów rozpuszczalności? Interesuje mnie wersja do napojów instant.
We’ve been sourcing inositols from three different suppliers. Your 40:1 ratio explanation convinced us to consolidate. The fact that myo-inositol is nearly tasteless is a huge plus for our flavored sachets.
Do you offer custom particle size for Myo-Inositol for tablet compression? We need a specific mesh size for for our inositol blend.
Yes, we offer OEM/ODM with custom particle size and solubility specifications. Bulk orders can be tailored to your tablet compression needs. Lead time is 7-15 days after spec confirmation. – Core Nutrix Team
Vi testar båda isomererna i vår R&D-avdelning. Att DCI inte ska användas ensamt är en viktig påminnelse – vi såg sämre resultat i våra egna pilotstudier med hög DCI-dos. Bra att ni tar upp det.
航空便で7-15日、船便で25-35日です。バルク25kgでDHL/FedExも可能です。在庫サンプルは1-3日で出荷できます。 – Core Nutrix Team
日本への配送はどのくらいかかりますか？DCIの25kgバルク注文で、船便と航空便のリードタイムを教えてください。
Enfin un article qui clarifie le ratio 40:1. Nous formulons pour le marché français et cherchions des données concrètes pour justifier notre composition. Le point sur la solubilité du myo-inositol est très utile pour nos sachets. Merci.
Sim, cada lote sai com COA e MSDS completos. Também enviamos relatórios HPLC/UV com rastreabilidade. Certificados ISO, HACCP, Kosher e Halal disponíveis sob solicitação. – Core Nutrix Team
Vocês têm certificado de análise e ficha de segurança para o Myo-Inositol? Preciso para auditoria interna.
Sí, enviamos muestras gratis a México (el comprador cubre el flete). El MOQ es 1 kg para muestra y 25 kg para pedido regular. Envío por DHL o FedEx en 1-3 días. – Core Nutrix Team
¿Pueden enviar muestras de D-Chiro-Inositol a México? ¿Cuál es el MOQ para una orden de prueba?